IntroductionThere is a paucity of clinical guidelines for the routine assessment of maladaptive reproductive grief reactions in outpatient primary care and OB-GYN settings in the United States. Because of the disenfranchised nature of perinatal grief reactions, many clinicians may be apt to miss or dismiss a grief reaction that was not identified in the perinatal period. A significant number of those experiencing a reproductive loss exhibit signs of anxiety, depression, or post-traumatic stress disorder. Reproductive losses are typically screened for and (...) recorded numerically as part of a woman’s well-visit intake, yet this process often fails to identify patients emotionally troubled by a prior pregnancy loss.Materials and MethodsA summative content analysis of 164 recent website blogs from female participants who self-reported having experienced a miscarriage or abortion in their lifetime was conducted. The narratives were reviewed for details regarding the time span between the pregnancy loss and the composition of the blog post. The stories were analyzed for subsequent relationship problems and detrimental mental health conditions. Maladaptive reactions were contrasted for those that indicated a greater than 12 months’ time-lapse and those who had not.ResultsMore than a third of the women reported in the narrative that at least one year or more had passed since experiencing the miscarriage or abortion. For those women, the median time span between the loss and composing the blog was 4 years with a range of 47 years. Mental health conditions attributed to the reproductive loss by those who reported longer bereavement times included subsequent relationship problems, substance misuse, depression, suicidal ideation, and PTSD. The percent of reported maladaptive issues was more than double for those who reported that a year or more had passed since the loss of the pregnancy.DiscussionGrief reactions following the loss of a pregnancy may be prolonged or delayed for several months which can contribute to adverse biopsychosocial outcomes. Recognition and treatment of maladaptive grief reactions following a pregnancy loss are critical. Screening methods should be enhanced for clinicians in medical office settings to help identify and expedite the appropriate mental health assistance. (shrink)

Sensorimotor learning refers to improvements that occur through practice in the performance of sensory-guided motor behaviors. Leveraging novel technical capabilities of an immersive virtual environment, we probed the component kinematic processes that mediate sensorimotor learning. Twenty naïve subjects performed a simulated marksmanship task modeled after Olympic Trap Shooting standards. We measured movement kinematics and shooting performance as participants practiced 350 trials while receiving trial-by-trial feedback about shooting success. Spatiotemporal analysis of motion tracking elucidated the ballistic and refinement phases of hand (...) movements. We found systematic changes in movement kinematics that accompanied improvements in shot accuracy during training, though reaction and response times did not change over blocks. In particular, we observed longer, slower, and more precise ballistic movements that replaced effort spent on corrections and refinement. Collectively, these results leverage developments in immersive virtual reality technology to quantify and compare the kinematics of movement during early learning of full-body sensorimotor orienting. (shrink)

The use of genetic technology in agriculture is viewed by some as the next frontier of farming but others may view it as a threat. The aim of the current study was to describe the views of experts working in agricultural genetics regarding how best to communicate genetic technology with a broader audience (e.g., clientele, the public). We recruited 10 experts working in roles that involve communication about genetic technology in agriculture. Using semi-structured interviews, we asked participants to describe how (...) they discuss this technology, who they discuss it with, and their thoughts on the involvement of various stakeholders in these discussions. Interview transcripts were subjected to thematic analysis and participant responses were organized into three themes: 1) Communicating and framing genetic technology, including discussing risks, benefits, and applications, distinguishing technology from other similar technologies, and engaging in value-based discussions; 2) Challenges of public communication, including misinformation and opposing opinions, conflation with older technologies, and balancing information provision; and 3) Stakeholder involvement in discussions, which included views on how different groups (e.g., activists, farmers, and scientists) should be included in discussions, and who is best suited to discuss genetic technology with the public. We conclude that leaders in agricultural genetics engage in a variety of approaches to communicate genetic technology, using different frames that they feel are likely to appeal to their audience, and differ in their opinions of who should be involved in these discussions. (shrink)

Some photographs show determinate features of a scene because the photographed scene had those features. This dependency relation is, rightly, a consensus in philosophy of photography. I seek to refute many long-established theories of photography by arguing that they are incompatible with this commitment. In Section II, I classify accounts of photography as either single-stage or multi-stage. In Section III, I analyze the historical basis for single-stage accounts. In Section IV, I explain why the single-stage view led scientists to postulate (...) “latent” photographic images as a technical phenomenon in early chemical photography. In Section V, I discredit the notion of an invisible latent image in chemical photography and, in Section VI, extend this objection to the legacy of the latent image in digital photography. In Section VII, I appeal to the dependency relation to explain why the notion of a latent image makes the single-stage account untenable. Finally, I use the multi-stage account to advance debate about “new” versus “orthodox” theories of photography. (shrink)

This article provides a critical comparative analysis of the substantive and procedural values and ethical concepts articulated in guidelines for allocating scarce resources in the COVID-19 pandemic. We identified 21 local and national guidelines written in English, Spanish, German and French; applicable to specific and identifiable jurisdictions; and providing guidance to clinicians for decision making when allocating critical care resources during the COVID-19 pandemic. US guidelines were not included, as these had recently been reviewed elsewhere. Information was extracted from each (...) guideline on: 1) the development process; 2) the presence and nature of ethical, medical and social criteria for allocating critical care resources; and 3) the membership of and decision-making procedure of any triage committees. Results of our analysis show the majority appealed primarily to consequentialist reasoning in making allocation decisions, tempered by a largely pluralistic approach to other substantive and procedural values and ethical concepts. Medical and social criteria included medical need, co-morbidities, prognosis, age, disability and other factors, with a focus on seemingly objective medical criteria. There was little or no guidance on how to reconcile competing criteria, and little attention to internal contradictions within individual guidelines. Our analysis reveals the challenges in developing sound ethical guidance for allocating scarce medical resources, highlighting problems in operationalising ethical concepts and principles, divergence between guidelines, unresolved contradictions within the same guideline, and use of naïve objectivism in employing widely used medical criteria for allocating ICU resources. (shrink)

According to the standard model of cosmology, Λ\documentclass[12pt]{minimal} \usepackage{amsmath} \usepackage{wasysym} \usepackage{amsfonts} \usepackage{amssymb} \usepackage{amsbsy} \usepackage{mathrsfs} \usepackage{upgreek} \setlength{\oddsidemargin}{-69pt} \begin{document}$$\Lambda $$\end{document}CDM, the mass-energy budget of the current stage of the universe is not dominated by the luminous matter that we are familiar with, but instead by some form of dark matter (and dark energy). It is thus tempting to adopt scientific realism about dark matter. However, there are barely any constraints on the myriad of possible properties of this entity—it is not even certain (...) that it is a form of matter. In light of this underdetermination I advocate caution: we should not (yet) be dark matter realists. The “not(-yet)-realism” that I have in mind is different from Hacking’s (Philos Sci 56 (4), 555–581, 1989) anti-realism, in that it is semantic rather than epistemological. It also differs from the semantic anti-realism of logical empiricism, in that it is naturalistic, such that it may only be temporary and does not automatically apply to all other unobservables (or even just to all other astronomical unobservables, as with Hacking’s anti-realism). The argument is illustrated with the analogy of the much longer history of the concept of a gene, as the current state of the concept of dark matter resembles in some relevant ways that of the early concept of genes. (shrink)

Extensive research has demonstrated that rs1360780, a common single nucleotide polymorphism within the FKBP5 gene, interacts with early-life stress in predicting psychopathology. Previous results suggest that carriers of the TT genotype of rs1360780 who were exposed to child abuse show differences in structure and functional activation of emotion-processing brain areas belonging to the salience network. Extending these findings on intermediate phenotypes of psychopathology, we examined if the interaction between rs1360780 and child abuse predicts resting-state functional connectivity (rsFC) between the (...) amygdala and other areas of the salience network. We analyzed data of young European adults from the general population (N = 774; mean age = 18.76 years) who took part in the IMAGEN study. In the absence of main effects of genotype and abuse, a significant interaction effect was observed for rsFC between the right centromedial amygdala and right posterior insula (p <.025, FWE-corrected), which was driven by stronger rsFC in TT allele carriers with a history of abuse. Our results suggest that the TT genotype of rs1360780 may render individuals with a history of abuse more vulnerable to functional changes in communication between brain areas processing emotions and bodily sensations, which could underlie or increase the risk for psychopathology. (shrink)

In the face of limited time and escalating impacts, some scientists and politicians are talking about attempting "grand technological interventions" into the Earth’s basic physical and biological systems ("geoengineering") to combat global warming. Early ideas include spraying particles into the stratosphere to block some incoming sunlight, or "enhancing" natural biological systems to withdraw carbon dioxide from the atmosphere at a higher rate. Such technologies are highly speculative and scientific development of them has barely begun. -/- Nevertheless, it is widely (...) recognized that geoengineering raises critical questions about who will control planetary interventions, and what responsibilities they will have. Central to these questions are issues of justice and political legitimacy. For instance, while some claim that climate risks are so severe that geoengineering must be attempted, others insist that the current global order is so unjust that interventions are highly likely to be illegitimate and exacerbate injustice. Such concerns are rarely discussed in the policy arena in any depth, or with academic rigor. Hence, this book gathers contributions from leading voices and rising stars in political philosophy to respond. It is essential reading for anyone puzzled about how geoengineering might promote or thwart the ends of justice in a dramatically changing world. (shrink)

Many services can assist autistic people, such as early intervention, vocational services, or support groups. Scholars and activists debate whether such services should be autism-specific or more general/inclusive/mainstream. This debate rests on not only clinical reasoning, but also ethical and social reasoning about values and practicalities of diversity and inclusion. This paper presents qualitative results from a mixed-methods study. An online survey asked autistic adults and parents of autistic people of any age in Canada, the United States, Italy, France, (...) and Germany what types of services they prefer (autism-specific, mixed-disability, or general/inclusive/mainstream). This paper presents the advantages and disadvantages of different service types, identified through inductive thematic coding and organized into higher-level themes focusing on clinical, structural, societal, interpersonal, and personal aspects of services. Autism-specific services were praised for addressing autism needs, helping clinically, and providing interpersonal benefits of others understanding autism; general services were praised for inclusion, helping clinically, community obligations and awareness, and social skills development. Looking at the interaction of these different aspects in respondent narratives nuances debates about autism-specificity, with a complex interplay between clinical, interpersonal, and societal aspects. Clinical and social perspectives are not necessarily separate and opposed, but intertwined based on different understandings of inclusion. Compared to parents, adults focused more on harm/safety issues, enjoyment, and stereotyping among other themes, attending to personal themes. These findings do not identify one best service type, but suggest that determining the right service in a given context may be informed by definitions of and goals about inclusion. (shrink)

Recent advances in the neuroscience of episodic memory provide a framework to integrate object relations theory, a psychoanalytic model of mind development, with potential neural mechanisms. Object relations are primordial cognitive-affective units of the mind derived from survival- and safety-level experiences with caretakers during phase-sensitive periods of infancy and toddlerhood. Because these are learning experiences, their neural substrate likely involves memory, here affect-enhanced episodic memory. Inaugural object relations are encoded by the hippocampus-amygdala synaptic plasticity, and systems-consolidated by medial prefrontal cortex (...) (mPFC). Self- and object-mental representations, extracted from these early experiences, are at first dichotomized by contradictory affects evoked by frustrating and rewarding interactions (“partial object relations”). Such affective dichotomization appears to be genetically hardwired the amygdala. Intrinsic propensity of mPFC to form schematic frameworks for episodic memories may pilot non-conscious integration of dichotomized mental representations in neonates and infants. With the emergence of working memory in toddlers, an activated self- and object-representation of a particular valence can be juxtaposed with its memorized opposites creating a balanced cognitive-affective frame (conscious “integration of object relations”). Specific events of object relations are forgotten but nevertheless profoundly influence the mental future of the individual, acting (i) as implicit schema-affect templates that regulate attentional priorities, relevance, and preferential assimilation of new information based on past experience, and (ii) as basic units of experience that are, under normal circumstances, integrated as attractors or “focal points” for interactive self-organization of functional brain networks that underlie the mind. A failure to achieve integrated object relations is predictive of poor adult emotional and social outcomes, including personality disorder. Cognitive, cellular-, and systems-neuroscience of episodic memory appear to support key postulates of object relations theory and help elucidate neural mechanisms of psychodynamic psychotherapy. Derived through the dual prism of psychoanalysis and neuroscience, the gained insights may offer new directions to enhance mental health and improve treatment of multiple forms of psychopathology. (shrink)

A high percent of oxidative energy metabolism is needed to support brain growth during infancy. Unhealthy diets and limited nutrition, as well as other environmental insults, can compromise these essential developmental processes. In particular, iron deficiency anemia has been found to undermine both normal brain growth and neurobehavioral development. Even moderate ID may affect neural maturation because when iron is limited, it is prioritized first to red blood cells over the brain. A primate model was used to investigate the neural (...) effects of a transient ID and if deficits would persist after iron treatment. The large size and postnatal growth of the monkey brain makes the findings relevant to the metabolic and iron needs of human infants, and initiating treatment upon diagnosis of anemia reflects clinical practice. Specifically, this analysis determined whether brain maturation would still be compromised at 1 year of age if an anemic infant was treated promptly once diagnosed. The hematology and iron status of 41 infant rhesus monkeys was screened at 2-month intervals. Fifteen became ID; 12 met clinical criteria for anemia and were administered iron dextran and B vitamins for 1–2 months. MRI scans were acquired at 1 year. The volumetric and diffusion tensor imaging measures from the ID infants were compared with monkeys who remained continuously iron sufficient. A prior history of ID was associated with smaller total brain volumes, driven primarily by significantly less total gray matter and smaller GM volumes in several cortical regions. At the macrostructual level, the effect on white matter volumes was not as overt. However, DTI analyses of WM microstructure indicated two later-maturating anterior tracts were negatively affected. The findings reaffirm the importance of iron for normal brain development. Given that brain differences were still evident even after iron treatment and following recovery of iron-dependent hematological indices, the results highlight the importance of early detection and preemptive supplementation to limit the neural consequences of ID. (shrink)

Translations, whether in the form of text, illustration, or interpretive analysis, served knowledge-making in multiple ways. It offered a refuge, severed contexts, and concealed the various workers that created it. Over the course of the seventeenth century, European naturalists in Istanbul, such as Luigi Ferdinando Marsigli (1658–1730), procured illustrations of Ottoman nature as fundamental resources to identify, collect, and compare indigenous plants and newly bred varieties. Despite maintaining an actual mediation for cross-cultural interactions, these sources of virtual communication remain largely (...) forgotten in modern scholarship. This article argues that this curious yet invisible corpus was not a nonagentive medium in an alienated leisure of a gentleman-scholar; instead, these illustrations were designed to call upon the viewer’s constant attention in self-motivated scientific labor. Such handy tools responded and contributed to early modern scholars’ modes of working, and in exchange they determined these sources’ own function, position, and visibility – either as a by-product or as a derivative. It is therefore only when integrated into the labor history of science that the degrees of invisibility pertaining to both Ottoman nature studies and self-directed labor can come into a granular view. (shrink)

Human attitudes to animals have changed as non-humans have become more widely incorporated in the category of moral agents who deserve some respect. Parallels between the functioning of humans and non-humans have been made for thousands of years but the idea that the animals that we keep can suffer has spread recently. An improved understanding of motivation, cognition and the complexity of social behaviour in animals has led in the last 30 years to the rapid development of animal welfare science. (...) Early attempts to define welfare referred to individuals being in harmony with nature but the first usable definition incorporated feelings and health as part of attempts to cope with the environment. Others considered that welfare is only about feelings but it is argued that as feelings are mechanisms that have evolved they are a part of welfare rather than all of it. Most reviews of welfare now start with listing the needs of the animal, including needs to show certain behaviours. This approach has used sophisticated studies of what is important to animals and has replaced the earlier general guidelines described as freedoms. Many measures of welfare are now used and indicate how good or how poor the welfare is. Naturalness is not a part of the definition of welfare but explains why some needs exist. In recent years, welfare has become established as one of various criteria used to decide on whether a system is sustainable because members of the public will not accept systems that cause poor welfare. The study of welfare has become part of the scientific basis upon which important political decisions are made. (shrink)

During the postwar period, the concept of instinct came to encapsulate the debate around the importance of nature versus nurture. The fact that animals show highly organized behavior early in development suggested the presence of an underlying fixity where behavior was “inbuilt” into an animal’s biology despite an individual’s experiences. This placed a discrete and exhaustive line between the innate and acquired that became a foundation for the European-dominated field of ethology. Across the Atlantic, a group of comparative psychologists (...) led by the American Museum of Natural History’s T. C. Schneirla contested this approach, proposing that the study of animal behavior should avoid abstract dichotomies with a renewed focus on developmental processes. While Schneirla’s theoretical and empirical work shaped the modern study of animal behavior, his legacy requires revisiting in an era where the nature versus nurture debate is regaining prominence. In this article, I revisit Schneirla’s approach to behavior with a focus on his paper “Interrelationships of the ‘Innate’ and the ‘Acquired’ in Instinctive Behavior” (published in M. Autuori et al. (1956) _L’instinct dans le comportement des animaux et de l’homme_; Masson, Paris, pp. 387–452) for the journal’s “Classics in Biological Theory” collection; the paper is available as supplementary material in the online version of this article. A companion article (this issue; G. M. Kohn (2024) “A Discussion on Instinct, Paris, 1954”) presents the commentary that was published with it. (shrink)

Two opposing accounts of early language evolution, the compositional and the holistic, have become the subject of lively debate. It has been argued that an evolving compositional protolanguage would not be useful for communication until it reached a certain level of grammatical complexity. This paper offers a new, discourse-oriented perspective on the debate. It argues that discourse should be viewed, not as a level of language structure ‘beyond the sentence’, but as sequenced communicative behaviour, typically but not uniquely involving (...) language. This provides for continuity from exchanges making use of simple communicative resources such as single words and gestures to those making use of complex grammatical conventions. Supporting evidence comes from child language and from original experiments with adults using constrained language systems. The paper shows that the utility of emerging compositional language is not dependent on some critical level of complexity, and so defends the compositional account. (shrink)

In Wollstonecraft’s early writings, she articulates the foundational theological and philosophical principles that would underpin her work throughout her career. One difference between her early and later work lies in the way that the values to which she refers are combined. Whereas Wollstonecraft at first appeals to the separate ideals of independence, equality, and virtue, from the 1790s onwards she integrates these into a characteristic republican framework that was in common use amongst dissenting theorists at the time. The (...) set of values on which Wollstonecraft draws, and the version of the republican framework that she develops, closely resemble those of Richard Price with whose work she was familiar. Examining the structural similarities between their respective models, I argue, gives us an insight into the systematic manner of aspects of Wollstonecraft’s own thought. It also allows us to see how Wollstonecraft goes beyond the republicanism of Price and others as she develops her own feminist solutions to the problems of structural domination. (shrink)

We report the identification of a recurrent, 520-kb 16p12.1 microdeletion associated with childhood developmental delay. The microdeletion was detected in 20 of 11,873 cases compared with 2 of 8,540 controls and replicated in a second series of 22 of 9,254 cases compared with 6 of 6,299 controls. Most deletions were inherited, with carrier parents likely to manifest neuropsychiatric phenotypes compared to non-carrier parents. Probands were more likely to carry an additional large copy-number variant when compared to matched controls. The clinical (...) features of individuals with two mutations were distinct from and/or more severe than those of individuals carrying only the co-occurring mutation. Our data support a two-hit model in which the 16p12.1 microdeletion both predisposes to neuropsychiatric phenotypes as a single event and exacerbates neurodevelopmental phenotypes in association with other large deletions or duplications. Analysis of other microdeletions with variable expressivity indicates that this two-hit model might be more generally applicable to neuropsychiatric disease. © 2010 Nature America, Inc. All rights reserved. (shrink)

In the emergent field of creative practice higher degrees by research, first generation supervisors have developed new models of supervision for an unprecedented form of research, which combines creative practice and a written thesis. In a national research project, entitled ‘Effective supervision of creative practice higher research degrees’, we set out to capture and share early supervisors’ insights, strategies and approaches to supporting their creative practice PhD students. From the insights we gained during the early interview process, we (...) expanded our research methods in line with a distributed leadership model and developed a dialogic framework. This led us to unanticipated conclusions and unexpected recommendations. In this study, we primarily draw on philosopher and literary theorist Mikhail Bakhtin’s dialogics to explain how giving precedence to the voices of supervisors not only facilitated the articulation of dispersed tacit knowledge, but also led to other discoveries. These include the nature of supervisors’ resistance to prescribed models, policies and central academic development programmes; the importance of polyvocality and responsive dialogue in enabling continued innovation in the field; the benefits to supervisors of reflecting, discussing and sharing practices with colleagues; and the value of distributed leadership and dialogue to academic development and supervision capacity building in research education. (shrink)

The cosmological theory of the author, discussed in (Greben in Found Sci 15(2):153–176, 2010 ), has a number of implications for the interpretation of initial conditions and the fine-tuning problem as discussed by Vidal (Found Sci 15(4):375–393, 2010a ).

Context. The identification of the sources that reionized the Universe and their specific contribution to this process are key missing pieces of our knowledge of the early Universe. Faint star-forming galaxies may be the main contributors to the ionizing photon budget during the epoch of reionization, but their escaping photons cannot be detected directly due to inter-galactic medium opacity. Hence, it is essential to characterize the properties of faint galaxies with significant Lyman continuum photon leakage up to z 4 (...) to define indirect indicators allowing analogues to be found at the highest redshift. Aims. Long gamma-ray bursts explode typically in star-forming regions of faint, star-forming galaxies. Through LGRB afterglow spectroscopy it is possible to detect directly LyC photons. Our aim is to use LGRBs as tools to study LyC leakage from faint, star-forming galaxies at high redshift. Methods. Here we present the observations of LyC emission in the afterglow spectra of GRB 191004B at z = 3:5055, together with those of the other two previously known LyC-emitting LGRB, to determine their LyC escape fraction and compare their properties. Results. From the afterglow spectrum of GRB 191004B we determine a neutral hydrogen column density at the LGRB redshift of og =17:2 0:15, and negligible extinction. The only metal absorption lines detected are C iv and Si iv. In contrast to GRB 050908 and GRB 060607A, the host galaxy of GRB 191004B displays significant Ly emission. From its Ly emission and the non-detection of Balmer emission lines we constrain its star-formation rate to 1 SFR 4:7 M yr. 1. We fit the Ly emission with a shell model and find parameters values consistent with the observed ones. The absolute LyC escape fractions we find for GRB 191004B, GRB 050908 and GRB 060607A are of 0:35+0:10.0:11, 0:08+0:05.0:04 and :20+0:05.0:05, respectively. We compare the LyC escape fraction of LGRBs to the values of other LyC emitters found from the literature, showing that LGRB afterglows can be powerful tools to study LyC escape for faint high-redshift star-forming galaxies. Indeed we could push LyC leakage studies to much higher absolute magnitudes. The host galaxies of the three LGRB presented here have all M1600 >.19:5 mag, with the GRB 060607A host at M1600 >.16 mag. LGRB hosts may therefore be particularly suitable for exploring the ionizing escape fraction in galaxies that are too faint or distant for conventional techniques. Furthermore the time investment is very small compared to galaxy studies. (shrink)

INTERNATIONAL STUDIES IN THE PHILOSOPHY OF SCIENCE Vol. 10, number 2, 1996, pp. 127-140. R.M. Nugayev. Why did the new physics force out the old ? Abstract. The aim of my paper is to demonstrate that special relativity and the early quantum theory were created within the same programme of statistical mechanics, thermodynamics and Maxwellian electrodynamics reconciliation. I’ll try to explain why classical mechanics and classical electrodynamics were “refuted” almost simultaneously or, in other words, why the quantum revolution and (...) the relativistic one both took place at the beginning of the 20th century. I’ll argue that the quantum and relativistic revolutions were simultaneous since they had a common origin – the clash beyween the mature theories of the second half of the 19th century that constituted the “body” of classical physics. The revolution’s most dramatic point was Einstein’s 1905 photon paper that laid the foundations of both special relativity and the old quantum theory. Hence the dialectic of the old theories is crucial for theory change. Later, classical physics was forced out by the joint development of quantum and relativistic subprogrammes. The title of my paper can be reformulated in Bruno Latour’s terms: The Einstein Revolution or Drawing Models Together. -/- . (shrink)

The three studies presented here examine children’s ability to make diagnostic inferences about an interactive causal structure across different domains. Previous work has shown that children’s abilities to make diagnostic inferences about a physical system develops between the ages of 5 and 8. Experiments 1 ( N = 242) and 2 ( N = 112) replicate this work with 4- to 10-year-olds and demonstrate that this developmental trajectory is preserved when children reason about a closely matched biological system. Unlike Experiments (...) 1 and 2, Experiment 3 ( N = 110) demonstrates that children struggle to make similar inferences when presented with a parallel task about category membership in biology. These results suggest that children might have the basic capacity for diagnostic inference at relatively early ages, but that the content of the inference task might interfere with their ability to demonstrate such capacities. (shrink)

This article examines the authenticity of an anonymous question on local motion extant in manuscript Madrid, Biblioteca Nacional, 4229. This quaestio discusses the motion of three types of mobile objects, namely celestial bodies, heavy and light bodies, and projectiles. A comparison of this anonymous text with three questions from the Sentences commentary of Giraldus Odonis shows that this Franciscan theologian is very likely to be the author of the anonymous question found in the Madrid manuscript, even if the precise relation (...) between Giraldus's questions, on the one hand, and the anonymous question De motu, on the other, remains uncertain. An edition of the anonymous question is given in an appendix. (shrink)

I undertook this review to celebrate Daniel Albright’s contributions to the theory of interrelations among the arts, and had nearly completed it before learning that he had died early in 2015. Apparently, he wrote Panaesthetics while fighting a fatal illness; it seems to have weakened him to the point where he could still display, but not longer coordinate, the contents of his magnificently furnished mind. The Yale press, often supportive of Yale graduates, published it anyway. Although this book itself (...) unfortunately cannot be recommended, the issues it raises are still of vital interest, and are discussed below. See the list of Albright’s many earlier books in the posthumous Wikipedia article devoted to him, and... (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Research Ethics after World War II: The Insular Culture of BiomedicineAllan M. Brandt (bio) and Lara Freidenfelds (bio)Human subjects research in the United States has only recently emerged as an important area of historical investigation. Over the last quarter century, scholars have begun the process of grounding within an historical context both the complex relationship between researchers and subjects and the processes by which biomedical knowledge is produced. Their (...) studies examine topics ranging from the impact of the anti-vivisectionist movement on human experimentation in the early twentieth century (Lederer 1995) to the development of the discipline of bioethics in the 1960s and 1970s (Rothman 1991) and the emergence of the legal concept of informed consent for human research (Katz, Glass, and Capron 1972). Many of the discussions focus on isolated incidents of scandal, such as the Tuskegee Syphilis Study (Jones 1993; Brandt 1978) and the Willowbrook School hepatitis study (Rothman and Rothman 1984). In doing so, they attempt to explain how such clearly unethical research could have been initiated and what consequences have resulted from public knowledge of such research.Nonetheless, the broader historical contexts and implications of human subjects research have yet to be fully delineated. This project will be of crucial importance, not only for historians, but also for those concerned with research policy and medical ethics. The historical examination of human subjects research will provide further insight into the details of research methods, the construction of protocols, and the historically specific interest in certain diseases. In addition, scholars will better understand the relationships of power and authority between researcher and subject, as well as the social and scientific mechanisms for the production of new biomedical knowledge. The process of enlisting research subjects illuminates the significance of class, gender, ethnicity, and race in science, in biomedicine, and in society. The fact that, historically, much research has employed research subjects from vulnerable populations, who participated in coercive contexts, has exposed powerful social assumptions embedded in the research enterprise. [End Page 239]The revelation of new documents indicating past abuses has sparked much of the investigation into human subjects research and the recent investigation of human radiation experiments during the Cold War era. One of the most important achievements of the Advisory Committee on Human Radiation Experiments was the uncovering of thousands of documents, a remarkable mine of archival data, that had been previously inaccessible to researchers. Jonathan Moreno and Susan Lederer’s article on the history of Cold War research ethics in this issue of the Kennedy Institute ofEthics Journal represents the first attempt since the publication of the Committee’s Final Report to analyze the Committee’s findings in a serious historical context.Historical accounts of the emergence of bioethics traditionally have left a great void in their discussions of human experimentation, generally ignoring the period between the writing of the Nuremberg Code in 1947 and the publication of Henry Beecher’s 1966 New England Journal ofMedicine article condemning systematic, unethical practices in human experimentation (Rothman 1991). The period from 1946 to 1966, however, was a time of vigorous research characterized by a fragmented community of medical researchers who applied inconsistent ethical standards and employed highly variable research practices. Both military and civilian medical researchers were intensely interested in radiation and thus conducted human subjects research along those lines, including examinations of the effects of plutonium injections and of total body irradiation, the use of trace radioisotopes to study various body processes, and observations of the effects of radiation intentionally released into the environment. The U.S. Government sponsored several thousand such studies (ACHRE 1995 [GPO, pp. 227–31; Oxford, pp. 135–38]), some of which were conducted on hospital patients, institutionalized children, military personnel, and prisoners. The Cold War scientific culture that produced this research must be examined from an historical ethical perspective.A central aspect of the culture of biomedical science after World War II was its insularity. Increasingly high standards of admission and challenging training had come to ensure that only a select group of individuals was admitted to the professions of medicine and research science. In this culture of experts, trustworthiness and ethical judgment were considered to be dependent upon expertise... (shrink)

Broadening participation in early science, technology, engineering and math learning outside of school is important for families experiencing poverty. We evaluated variations of the Teaching Together STEM pre-kindergarten program for increasing parent involvement in STEM learning. This informal STEM, family engagement program was offered in 20 schools where 92% of students received free/reduced lunch. The core treatment included a series of family education workshops, text messages, and family museum passes. The workshops were delivered at school sites by museum outreach (...) educators. We randomly assigned schools to business-as-usual control or one of three additive treatment groups. Using an additive treatment design, we provided the core program in Treatment A, we added take-home STEM materials in Treatment B, and added materials + parent monetary rewards in Treatment C. The primary outcome was parent involvement in STEM. There were no significant impacts of any treatment on parent involvement; however, the groups that added take-home materials had larger effect sizes on parent involvement at posttest and later, kindergarten follow-up. Adding parent monetary rewards only produced short-term improvements in parent involvement that faded at follow-up. We discuss implications for other community-sponsored family engagement programs focused on informal STEM learning, including considering characteristics of families who were more versus less likely to attend. These null findings suggest that alternatives to in-person family education workshops should be considered when parents are experiencing poverty and have competing demands on their time. (shrink)

When Introduction à la méthode de Léonard de Vinci was published, Valéry was not yet twenty-four. The period during which he wrote this work, as well as Soirée avec M. Teste, which appeared a year later, was extremely important in his biography, for it defined the principal trends of his thought for decades to come. After a twenty-year period of silence and retirement, there appeared his small volume La Jeune Parque, the collection Charmes, Album de vers anciens, and his Socratic (...) dialogues, all of which won him fame. The reader became aware of a brilliant stylist producing essays most abundant in number and themes, an acute analyst of culture in crisis, of the human community, mind, and morals, and the author of notebooks kept for many years in which he appears, as, among other things, a forerunner of the most diverse ideas in the realm of linguistics, psychology, information theory, aesthetic theory, and the like. Finally, there was to be the posthumous publication of Mon Faust, which, in the mind of the more perceptive reader, markedly emphasizes and sharpens the tragic aspects of Valéry's personality and consciousness of the world, for he is still today sometimes presented as a kind of causeur of high society, a cold master of "manufactured" poetry, an overly brilliant dilettante blinded by science or, at the very best, an utterly academic classicist in the category of those who are as dead as Bossuet or Boileau. All that was still in the future. However, it was precisely in these early works that, with all the fire of youth and maximalism of thought, he formulated ideas that must be central to the attention of those who wish to discover the system of Paul Valéry. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Reviewed by:Hypatia’s Daughters: Fifteen Hundred Years of Women Philosophers ed. by Linda Lopez McAllisterSue M. WeinbergLinda Lopez McAllister, editor. Hypatia’s Daughters: Fifteen Hundred Years of Women Philosophers. Bloomington and Indianapolis: Indiana University Press, 1996. Pp. xiv + 345. Cloth, $49.95. Paper, $22.50.Hypatia: born in the fourth century A.D.: philosopher, mathematician, astronomer, teacher; brutally murdered in Alexandria in 415 A.D—whether for holding religious views regarded as heretical or because she (...) was a woman who dared to be a scholar and teacher remains a matter of speculation. Today, she gives her name to the journal for feminist philosophy. She is a symbol for those women who, over the centuries, have struggled to be part of the philosophical life of their time.Until very recently, the centuries that separated Hypatia from the present were assumed to have been a philosophical desert for women. But times have changed. Hypatia’s Daughters is a sign of this change. It contains eighteen articles on seventeen philosophers: Hypatia; Hildegard of Bingen, Heloise, and Christine de Pisan from the Middle Ages; Elizabeth of Bohemia, Sor Juana de la Cruz, Anne Conway, Damaris Masham, Catharine Trotter, Belle van Zuylen and Mary Wollstonecraft from the seventeenth and eighteenth centuries; Anne Doyle Wheeler and Harriet Taylor Mill from the nineteenth; Charlotte Perkins Oilman, Edith Stein, Hannah Arendt, and Angela Davis from the late nineteenth century into contemporary times. Few are known as well as they deserve, but many names are familiar even to non-specialists. Their ideas, however, are another matter.The collection in no way constitutes a definitive selection of women philosophers; those discussed are not presented as the most significant women philosophers in the history of philosophy. (A different kind of study would be necessary for evaluations of that kind.) The women here studied have little in common as a group; they wrote on many topics of philosophical concern; their views and their supporting reasoning differ. Further, as the subjects of the articles differ in their ideas, so do the contributors’ approaches and their methods of studying those ideas differ. These differences are the strengths of a collection that is stimulating, enlightening, provocative. The following examples indicate their range.Andrea Nye examines the correspondence of Heloise and Abelard and, in a second article, of Elizabeth of Bohemia and Descartes. Heloise and Elizabeth are usually regarded as passive followers or, at best, no more than serious questioners seeking answers of their correspondents. Nye’s fresh look at the Heloise-Abelard correspondence finds not only important differences between two ways of thinking, but also sees already underlying their disagreement what she calls the “macroquestion” of philosophy’s future: philosophy as “a professional discipline independent of political or social concerns or... an ongoing critical and cultural discourse.” (25) Elizabeth’s persistent questions to Descartes reveal ideas that challenge his views, especially on moral issues and physiological-psychological [End Page 164] phenomena; these are views that have a greater complexity than the basic issue of mind-body interaction that is usually identified as central to their exchange.Writing on Harriet Taylor Mill, Jo Ellen Jacobs examines changing attitudes towards her subject, beginning with views of Taylor Mill’s contemporaries and moving through the decades into our time. She finds parallels between criticisms of Taylor Mill and attitudes towards the so-called intellectual woman. In times encouraging of women, Taylor Mill is regarded as having made important contributions to the development of J. S. Mill’s thinking, in addition to writing and speaking about her own ideas and positions that did not always follow those of J. S. Mill. In less encouraging times, her significance tends to be minimized.Hannah Arendt is not usually thought of as a feminist. Joanne Cutting-Gray, through her discussion of Arendt’s early book on Rahel Varnhagen, develops implications of that study for Arendt as a “feminist thinker,” in particular through her focus on “the politics of alterity.” Cutting-Gray finds in the Varnhagen biography “an analogy between Jewish and female alterity [that] can stretch our understanding of women and politics.” (281)And there is more, much more: Martha Brandt Bolton’s scholarly examination of the philosophical works... (shrink)

The concept of hysteria is traced from Hippocrates, where it was thought to be caused by a wandering uterus, through Galen and up to Freud. Throughout the history of medicine from the early Greeks up to the end of the nineteenth century, the definition and diagnosis of hysteria had a function similar to that found in the persecution of witchcraft: it sought to eradicate the outbursts of nonconforming and emotionally threatening conduct of women. At the beginning of the twentieth (...) century, however, the category virtually disappears from psychiatric nosologies. (shrink)

Immanuel Kant's _Groundwork for the Metaphysics of Morals_ is widely regarded as one of the most influential works in the history of moral philosophy. Indeed, any student of ethics will soon encounter a translation of the book, although trying to read it is likely to cause bewilderment. What, one may ask, is Kant trying to say? This book provides the answers. Here, seven highly regarded teachers and scholars of Kant's ethics offer remarkably clear explanations of the most important concepts in (...) the _Groundwork_: the good will, happiness, duty, hypothetical and categorical imperatives, the Formula of Universal Law, the Formula of Humanity, and freedom._ Contents:_ Preface _The Good Will_, Nataliya Palatnik _Happiness_, Anne Margaret Baxley _Duty_, Laura Papish _Imperatives_, Tamar Schapiro _The Formula of Universal Law_, Kyla Ebels-Duggan _The Formula of Humanity_, Japa Pallikkathayil _Freedom_, Lucy Allais About the Contributors Index. (shrink)

Information and communication technologies (ICT) enable citizens to communicate across state borders with greater ease than ever before, exciting much speculation about the emergence of transnational public spheres. This highly original work introduces this debate to International Relations, by investigating the socio-political implications of ICT in a global governance framework. Classic Habermasian theory is radically reconstructed to take account of contemporary trends in state sovereignty and global civil society. It is argued that if access is not widened and free speech (...) not sufficiently protected, the early promise of ICT as a liberating force will be neutralized. (shrink)

Mythology is a very ancient, but at the same time a very vital form of creative fantasy. It is a dominant feature in the spiritual culture of primitive societies, and to some extent of ancient societies; it is the principal means of giving an overall sense to the world. In a primitive culture, mythology gives body to an as yet weakly differentiated syncretic unity of unconscious creation, primitive religion and the embryonic forms of pre-scientific notions about the surrounding world. Mythology (...) provides the soil and the raw material for early forms of religion and of poetry. (shrink)

Much of the research that has been carried out on occupational health and safety involves studies of regulatory practices. OHS studies linearly maintain that early legislations were of minimal consequence. Implementation is a two-tier structure—policy-making and enforcement. This article considers the main themes and findings of this body of research. It is structured around a “natural history” approach to understanding law. This approach regards law as a process which starts with the recognition of a problem demanding legal intervention and (...) the subsequent enactment of legislation. Several jurisdictions additionally encourage workers to join the enforcement procedure. Law being intrinsic to OHS, enforcement emerges as the key to explain its impact, while evidence suggests the role of sanctions on it. The article highlights areas that remain relatively uncharted and those that warrant more research. (shrink)

This is a puzzling book. On the one hand, Stoneham insists that “we cannot appreciate the contributions made by philosophers like Berkeley without coming to terms with the full breadth and detail of his thought”. On the other hand, his interpretive efforts are directed almost exclusively at the Three Dialogues between Hylas and Philonous—a work Berkeley intended as a popular recasting of his doctrines and one that scholars generally regard as conspicuously lacking the “full breadth and detail” of his philosophy. (...) There is an evident tension between the goal of thoroughly examining Berkeley’s thought and the chosen means of focusing on the Three Dialogues. This tension arises, in large part, from the fact that Stoneham’s intended audience is not Berkeley scholars, but rather people seriously interested in philosophy and its history, yet lacking significant familiarity with Berkeley’s thought or its background in early modern philosophy. As a way to introduce advanced undergraduates or graduate students to Berkeley, the book is a reasonably successful effort, although there are some significant shortcomings. (shrink)

In lieu of an abstract, here is a brief excerpt of the content:Journal of the History of Philosophy 42.2 (2004) 223-224 [Access article in PDF] Jacqueline Broad. Women Philosophers of the Seventeenth Century. New York: Cambridge University Press, 2002. Pp. x + 191. Cloth, $55.00. In this impressive study of early Modern Philosophy, Jacqueline Broad analyzes the influence that Cartesianism has had in the development of feminist thought. Her work covers the early modern philosophy of Elisabeth of Bohemia, (...) Margaret Cavendish, Ann Conway, Mary Astell, Damaris Cudworth Masham and Catherine Trotter Cockburn. She points out the paradoxical relationship between current feminist philosophy and the writings of early Modern women. Broad concentrates on the metaphysical issues of mind-body dualism, thinking matter, and the role of reason in knowledge.Recent feminists have argued that even though Cartesianism appears to emphasize an egalitarian concept of reason, it entails a male bias which excludes women from philosophy. Broad covers the work of Genevieve Lloyd, Hilda Smith, Margaret Atherton and other feminists. Her goal is to show that the common Cartesian interpretation of early women's writings obscures the anti-Cartesian and anti-dualist aspects of their thought. Like Lloyd, she argues that historically women were associated with a lesser form of reason following the rise of Cartesianism.The conflict between reason and femininity is noted in the complexity of early Modern thought. Broad argues that even though Elisabeth is remembered as a critic of Descartes, many of her suggestions are not as anti-dualist as some scholars believe. Broad highlights the critical content of Elisabeth's letters to Descartes and discusses her criticisms of dualism and her Cartesian method of discovering truth and certainty. On the basis of her letters she contends that Elisabeth can be regarded as a precursor to feminist philosophers who give an equal role to the body and emotions in their metaphysical and ethical writings.Like Elisabeth, Margaret Cavendish rejects Cartesian dualism. The common thread that runs through early Modern feminist philosophy is the argument that interaction between two unlike substances is inconceivable. Broad argues that like Cavendish, Anne Conway ascribes spiritual characteristics to the body and material properties to the soul. According to Broad, their ontological views amount to a rejection of the stereotypes of femininity.Broad argues that Mary Astell's metaphysical views diverge from the modern Cartesians of her time. Although she is indebted to Descartes, Broad contends that she supports a metaphysical system which avoids some of the gender biases identifiable in Cartesianism. Astell, for example, does not find a life based on reason as a rival to a life concerned with the body; her emphasis on rationality is simply a reaction to the stereotype of women as irrational material beings.Damaris Masham is generally considered a philosophical rival of Astell, but Broad argues that Masham's arguments are focused on the same presuppositions as Astell's. She argues that both philosophers champion women's education, criticize the occasionalism of Norris and believe in interaction between the corporeal and incorporeal worlds. Broad emphasizes the common theological outlook inspired by Cambridge Platonism. Contrary to the interpretation of Ruth Perry, she finds that there is sufficient evidence that Masham was positively inspired by the second part of Astell's Serious Proposal.Broad concludes with an analysis of Catherine Cockburns' metaphysics and moral philosophy. According to Cockburn, women's ignorance is simply the result of being discouraged from rational pursuits. Cockburn's defense of Locke's notion of thinking matter and her rejection of Cartesian notions of substance mark the end of the Cartesian influence on women philosophers in England. [End Page 223]Broad has shown that a reverence for reason and dualistic theories do not necessarily go hand in hand. She points out that early Modern feminist thinkers are not simply handmaidens to the great philosophical masters. As other scholars have argued, one can find unique approaches to substance as well as original moral positions.This text is a significant contribution to the literature on early Modern philosophy. Broad's in depth analysis will not fail to interest scholars in metaphysics, the history of philosophy and moral theory. Kathy... (shrink)

The question of a new journal and the philosophical debate of 1947 In 1922-43 Soviet philosophers had their own journal titled Pod znamenem marksizma [Under the Banner of Marxism]. It came into being in early 1922 and its third issue contained Lenin's programmatic article "On the Significance of Militant Materialism" [O znachenii voinstvuiushchego materializma]. This journal published many good combative articles in its twenty years. But during the War it fell ill and in mid-1943 ceased to exist. It was (...) not discontinued. No, it simply lacked the strength to appear. Thereafter, we Soviet philosophers did not have our own journal for several years. The lack was felt especially keenly after the end of the Great Patriotic War when philosophical studies developed quickly in our country. A wide discussion of philosophical questions, especially contentious, controversial questions—and there were quite a few of them—became necessary but there was no forum for discussing them. This was also true of the critical analysis of the philosophical literature that was coming out: a rare review appeared from time to time in the existing journals, but it was clearly inadequate and, most importantly, it did not give a comprehensive evaluation of the merits and shortcomings of the published philosophical work. It seemed to us then that an unhealthy situation such as the one involving G. F. Aleksandrov's book The History of Western European Philosophy [Istoriia zapadnoevropeiskoi filosofii], which was not evaluated on its merits and, despite its serious flaws, was praised by admirers of the author's talent, could only arise in the absence of a philosophical journal. Had there been a journal, it could have helped to prevent such stuffy situations from arising in certain sections of the philosophical front. Obviously, this opinion was quite naive: at the time many of us did not understand that if Aleksandrov had had "his" man on the journal, no criticism of his book would have been permitted. We realized this later. (shrink)

In 1981 S. W. Hawking and J. Hartle presented a quantum mechanical description of the early stages of possible cosmological evolution. Their proposal was interpreted by many authors as a pattern of cosmic creation from nothing in which no divine Creator is needed. In this approach, physically defined “nothing” was identified both with the empty set of set theory and with metaphysical nothingness. After defining philosophical presuppositions implicitly assumed in Hawking's paper, one discovers that this alleged nothingness has all (...) properties of the philosophically conceived Logos accepted by Hellenic philosophers of the Neoplatonic tradition. Consequently, Hawking's theory of creation remains consistent with Christian theism, and its only theological opponents can be found among defenders of Samuel Clark's God of scientific gaps. (shrink)

Islamic philosophy; Hanbalites; doctrines; creation (Islam); early works to 1800.

The Secret Symmetry of Maimonides and Freud presents the parallels between The Guide of the Perplexed and The Interpretation of Dreams, considering how Maimonides might be perceived as anticipating Freud's much later work. In this volume, Nathan M. Szajnberg suggests that humankind has secrets to hide and does so by using common mechanisms and embedding revealing hints for the benefit of the true reader. Using a psychoanalytic approach in tandem with literary criticism and an in-depth assessment of Judaica, Szajnberg demonstrates (...) the similarities between these two towering Jewish intellectual pillars. Using concepts of esoteric literature from the Torah and later texts, this book analyses their ideas on concealing and revealing to gain a renewed perspective on Freud's view of dreams. Throughout, Szajnberg articulates the challenges of reading translated works and how we can address the pitfalls in such translations. The book is a vital read for psychoanalysts in training and practice, as well as those interested in Judaica, the history of ideas and early Medieval studies. (shrink)

There is a general sense that the philosophy of Descartes was a dominant force in early modern thought. Since the work in the nineteenth century of French historians of Cartesian philosophy, however, there has been no fully contextualized comparative examination of the various receptions of Descartes in different portions of early modern Europe. This study addresses the need for a more current understanding of these receptions by considering the different constructions of Descartes's thought that emerged in the Calvinist (...) United Provinces and Catholic France, the two main centers for early modern Cartesianism, during the period dating from the last decades of his life to the century or so following his death in 1650. It turns out that we must speak not of a single early modern Cartesianism rigidly defined in terms of Descartes's own authorial intentions, but rather of a loose collection of early modern Cartesianisms that involve a range of different positions on various sets of issues. Though more or less rooted in Descartes's somewhat open-ended views, these Cartesianisms evolved in different ways over time in response to different intellectual and social pressures. Chapters of this study are devoted to: the early modern Catholic and Calvinist condemnations of Descartes and the incompatible Cartesian responses to these; conflicting attitudes among early modern Cartesians toward ancient thought and modernity; competing early modern attempts to combine Descartes's views with those of Augustine; the different occasionalist accounts of causation within early modern Cartesianism; and the impact of various forms of early modern Cartesianism on both Dutch medicine and French physics. (shrink)

Oxford Scholarly Classics is a new series that makes available again great academic works from the archives of Oxford University Press. Reissued in uniform series design, the reissues will enable libraries, scholars, and students to gain fresh access to some of the finest scholarship of the last century.